FARBRO5 designs and makes thousands of selective, cell-permeable macrocycles for intracellular targets, benchmarked against experimental data before a single molecule is synthesised and screened, at a fraction of the cost of HTS.

~80% of high-value drug targets are intracellular. Small molecules lack selectivity. Biologics cannot enter the cell. Macrocycles occupy the space between them: large enough to engage complex binding sites with specificity, small enough to cross the membrane.

Our integrated computational design and array-based synthesis platform enables exploration of vast macrocycle chemical space at a scale and speed not previously achievable — with selectivity and cell-permeability built in from the start. 2 patent applications filed.